Molecular Mechanisms of Primary Hypercalciuria
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of primary hypercalciuria.
Nephrolithiasis, with a lifetime incidence of up to 13% (1–9), results in significant morbidity as well as substantial economic costs, not only directly from medical treatment but also indirectly through time lost from work. Approximately 70% of kidney stones are composed of calcium, generally combined with oxalate and/or phosphate (1,7). Hypercalciuria is the most consistent metabolic abnormal...
متن کاملPathogenesis of primary hypercalciuria
Hypercalciuria may be classified into absorptive, renal and resorptive forms, depending on whether the primary defect is intestinal hyperabsorption of calcium, renal leak of calcium, or excessive bone resorption. In absorptive hypercalciuria, the pathogenetic role of vitamin D is uncertain, and mutations in the chloride channel may occur mainly in association with Dent’s disease. Early studies ...
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Primary Hypercalciuria (PH) is very frequently accompanied by some degrees of bone demineralization. The most frequent clinical condition in which this association has been studied is calcium nephrolithiasis. In these patients bone density has been reported to be very frequently low and increased susceptibility to fragility fractures has been described. One of the most important aspects is the ...
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Prevalence of hypercalciuria is markedly increased in patients with calcium kidney stones, and recently it has been demonstrated that the risk to produce stones is positively related with the levels of calcium excretion in general population. The stonepromoting effect of hypercalciuria depends on the unusually high calcium concentrations in urine and tubular fluid, which favor calcium salt prec...
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Introduction: Pregnancy and health is the process in which the egg is fertilized and being able to survive. When pregnancy occurs under some conditions and the fetus is being at risk, it will lead to abortion that occurs involuntarily and spontaneously. Abortions that occur more than two or three times are called recurrent pregnancy loss (RPL). Various etiological factors involved in RPL, inclu...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2003
ISSN: 1046-6673,1533-3450
DOI: 10.1097/01.asn.0000062960.26868.17